BM8201 Syllabus FUNDAMENTALS OF BIO CHEMISTRY Regulation 2017 Anna University

BM8201 Syllabus OBJECTIVES:

The student should be:

To study structural and functional properties of carbohydrates, proteins, lipids and nucleic acids
To emphasize the role of these biomolecules by providing basic information on specific metabolic diseases and disorders of these biomolecules

BM8201 Syllabus UNIT I INTRODUCTION TO BIOCHEMISTRY

Introduction to Biochemistry, water as a biological solvent, weak acid and bases, pH, buffers, Handerson – Hasselbalch equation, physiological buffers in living systems, Energy in living organism. Properties of water and their applications in biological systems. Introduction to Biomolecules, Biological membrane, Clinical application of Electrolytes and radioisotopes

BM8201 Syllabus UNIT II CARBOHYDRATES

Classification of carbohydrates – mono, di, oligo and polysaccharides. Structure, physical and chemical properties of carbohydrates Isomerism, racemisation and mutarotation. Digestion and absorption of carbohydrates. Metabolic pathways and bioenergetics – Glycolysis, glycogenesis, glycogenolysis and its hormonal regulation. TCA cycle and electron transport chain. Oxidative phosphorylation. Biochemical aspect of Diabetes mellitus and Glycogen storage Disease.

BM8201 Syllabus UNIT III LIPIDS

Classification of lipids- simple, compound and derived lipids. Nomenclature of fatty acid, physical and chemical properties of fat..Metabolic pathways: synthesis and degradation of fatty acid (beta oxidation), hormonal regulation of fatty acid metabolism, ketogenesis, Biosynthesis of Cholesterol. Disorders of lipid metabolism.

BM8201 Syllabus UNIT IV NUCLEIC ACID & PROTEIN

Structure of purines and pyrimidines, nucleoside, nucleotide, DNA act as a genetic material, chargoffs rule. Watson and crick model of DNA. Structure of RNA and its type. Metabolism and Disorder of purines and pyrimidines nucleotide Classification, structure and properties of proteins, structural organization of proteins, classification and properties of amino acids. Separation of protein, Inborn Metabolic error of amino acid metabolism

BM8201 Syllabus UNIT V ENZYME AND ITS CLINICAL APPLICATION

Classification of enzymes, apoenzyme, coenzyme, holoenzyme and cofactors. Kinetics of enzymes – Michaelis-Menten equation.Factors affecting enzymatic activity: temperature, pH, substrate concentration and enzyme concentration. Inhibitors of enzyme action: Competitive, non- competitive, irreversible. Enzyme: Mode of action, allosteric and covalent regulation. Clinical enzymology. Measurement of enzyme activity and interpretation of units.

BM8201 Syllabus OUTCOMES:

Upon Completion of the Course

The students will be able to
Explain the fundamentals of biochemistry
Clinical application of Biochemistry

BM8201 Syllabus TEXT BOOKS:

1. RAFI MD ―Text book of biochemistry for Medical Student‖ Second Edition, University Press, 2014.

2. David.W.Martin, Peter.A.Mayes , Victor. W.Rodwell, ―Harper’s Review of Biochemistry‖, LANGE Medical Publications, 1981.

BM8201 Syllabus REFERENCES:

1. Keith Wilson & John Walker, ―Practical Biochemistry – Principles & Techniques‖, Oxford University Press, 2009.

2. Pamela.C.Champe & Richard.A.Harvey, ―Lippincott Biochemistry Lippincott’s Illustrated Reviews‖, Raven publishers,1994.

Subject Name	Fundamentals of Bio Chemistry
Subject Code	BM8201
Regulation	2017
File	PDF
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